Manuscripts
1. Eke OF, Selame L, Gullikson J, Deng H, Dutta S, Shokoohi H. Timing of pericardiocentesis and clinical outcomes: Is earlier pericardiocentesis better? Am J Emerg Med. 2022 Feb 3;54:202-207. doi: 10.1016/j.ajem.2022.01.062
2. Schleifer JI, Selame LAJ, Short Apellaniz J, Loesche M, Shokoohi H, Mehaffey C, Liteplo A. Sonographic Assessment of the Effects of Mechanical Ventilation on Carotid Flow Time and Volume. Cureus. 2021 Dec 21;13(12):e20587.
3. Huang C, Morone C, Parente J, Taylor S, Springer C, Doyle P, Temin E, Shokoohi H, Liteplo A. Advanced practice providers proficiency-based model of ultrasound training and practice in the ED. J Am Coll Emerg Physicians Open. 2022 Jan 11;3(1):e12645.
4. Schwid MR, Loesche MA, Macias-Konstantopoulos W, Shokoohi H. Racial and sex disparities in difficult intravenous access. Am J Emerg Med. 2021 Dec 24:S0735-6757(21)01023-
5. Duggan NM, Nagdev A, Hayes BD, Shokoohi H, Selame LA, Liteplo AS, Goldsmith AJ. Perineural Dexamethasone as a Peripheral Nerve Block Adjuvant in the Emergency Department: A Case Series. J Emerg Med. 2021 Nov;61(5):574-580
6. Selame LAJ, Matsas B, Krauss B, Goldsmith AJ, Shokoohi H. A Stepwise Guide to Performing Shoulder Ultrasound: The Acromio-Clavicular Joint, Biceps, Subscapularis, Impingement, Supraspinatus Protocol. Cureus. 2021 Sep 28;13(9):e18354. doi: 10.7759/cureus.
7. Stone A, Goldsmith AJ, Pozner CN, Vlassakov K. Ultrasound-guided regional anesthesia in the emergency department: an argument for multidisciplinary collaboration to increase access while maintaining quality and standards. Reg Anesth Pain Med. 2021 Sep;46(9):820-821.
8. Duanmu Y, Goldsmith AJ, Henwood PC, Platz E, Hoyler JE, Kimberly HH. Visual Estimation of Tricuspid Annular Plane Systolic Excursion by Emergency Medicine Clinicians. West J Emerg Med. 2020 Jul 10;21(4):1022-1028.
9. Selame LA, Risler Z, Zakaria SJ, Hughes LP, Lewiss RE, Kehm K, Goodsell K, Kalwani R, Mirsch D, Kluger SB, Au A. A comparison of homemade vascular access ultrasound phantom models for peripheral intravenous catheter insertion. J Vasc Access. 2021 Nov;22(6):891-897
10. Kharasch S, Dumas H, O’Brien J, Shokoohi H, Al Saud H, Liteplo A, Schleifer J, Kharasch V. Detecting Ventilator-Induced Diaphragm Dysfunction using Point-of-Care Ultrasound in Children with Long-Term Mechanical Ventilation. J Ultrasound Med. 2021;40(4):845-852.
11. Kharasch S, Cohen S. Pediatric Emergency Medicine Ultrasound Fellowships. Pediatric Emerg Care. 2021;37:425-426.
12. Schleifer J, Shokoohi H, Selame LA, Liteplo A, Kharasch S. The Use of Angle-Independent M-Mode in the Evaluation of Diaphragmatic Excursion: Towards Improved Accuracy. Cureus. In Press.
13. Goldsmith AJ, Al Saud AL, Duggan NM, Ma IW, Huang CK, Onyinyechi E, Kapur T, Kharasch,S, Liteplo A, Shokoohi H. Point-of-Care Lung Ultrasound for Differentiating Covid-19 from Influenza. Cureus 2022;DOI:10.7759/curues.2116
14. Selame LA, Davis JJ, Ma IWY, McFadden K, Huang C, Liteplo A, Goldsmith AJ, Shokoohi H. Do scan numbers predict point-of-care ultrasound use and accuracy in senior emergency medicine residents? Am J Emerg Med. 2021 Jan 23:S0735-6757(21)00040-1.
15. Negishi K, Apellaniz JS, Ratanski D, Frasure SE, Liteplo AS, Shokoohi H. Detection of adrenal mass during an educational point-of-care ultrasound in the emergency department. World J Emerg Med. 2021;12(2):154-156.
16. Schleifer J, Haney RM, Shokoohi H, Huang CK, Ratanski D, Kimberly H, Liteplo AS. Longitudinal accuracy analysis of ultrasound performed during a four-year emergency medicine residency. AEM Educ Train. 2021 Feb 17;5(3):e10574.
17. Al Saud A, Goldsmith A, Schulwolf S, Al Mulhim A, Eke O, Huang C, Kharasch S, Liteplo A, Shokoohi H. Ultrasound and Influenza: The Spectrum of Lung and Cardiac Ultrasound Findings in Patients with Suspected Influenza A and B, Ultrasound Med Biol. 2021 June;-Accepted for publication
18. Jacomino K, Frasure S E, Boniface K S, Shokoohi H. Point-of-Care Ultrasound in the Diagnosis of an Incarcerated Inguinal Hernia. Cureus 13(7): e16281. DOI 10.7759/cureus.16281
19. Schleifer J, Shokoohi H, Selame LA, Liteplo A, Kharasch S. The Use of Angle-Independent M-mode in the Evaluation of Diaphragmatic Excursion: towards improved accuracy . Cureus 2021-accepted for publication. DOI: 10.7759/cureus.17284
20. Amini R, Patanwala A E, Shokoohi H, Adhikari S. (August 18, 2021) Number Needed to Scan: Evidence-Based Point-of-Care Ultrasound (POCUS). Cureus 13(8): e17278. doi:10.7759/cureus.17278
21. Chardoli M, Sabbaghan Kermani S, Abdollahzade Manqoutaei S, Loesche MA, Duggan N, Schulwolf S, Tofighi R, Yadegari S, Shokoohi H. Lung Ultrasound in Predicting COVID-19 Clinical Outcomes: A Prospective Observational Study, JACEP Open- July 2021 Accepted for publication
22. Selame LA, McFadden K, Duggan NM, Goldsmith AJ, Shokoohi H. Ultrasound-Guided Transgluteal Sciatic Nerve Block for Gluteal Procedural Analgesia. J Emerg Med. 2021 Apr;60(4):512-516.
23. Shokoohi H, Duggan NM, Adhikari S, Selame LA, Amini R, Blaivas M. Point-of-care ultrasound stewardship. J Am Coll Emerg Physicians Open. 2020 Oct 11;1(6):1326-1331.
24. Shokoohi H, Loesche MA, Duggan NM, Liteplo AS, Huang C, Al Saud AA, McEvoy D, Liu SW, Dutta S. Difficult intravenous access as an independent predictor of delayed care and prolonged length of stay in the emergency department. J Am Coll Emerg Physicians Open. 2020 Aug 19;1(6):1660-1668.
25. Duggan NM, Selame LA, Shokoohi H. Why pretest probability matters when we do point-of-care ultrasound. J Am Coll Emerg Physicians Open. 2020 Dec 17;1(6):1778. doi: 10.1002/emp2.12331.
26. Al Mulhim AA, Schulwolf SL, McFadden KM, Shokoohi H. Transperineal Ultrasound in the Diagnosis of Proctitis in the Emergency Department. J Emerg Med. 2021 May;60(5):e119-e124.
27. Graglia S, Shokoohi H, Loesche MA, Yeh DD, Haney RM, Huang CK, Morone CC, Springer C, Kimberly HH, Liteplo AS. Prospective validation of the bedside sonographic acute cholecystitis score in emergency department patients. Am J Emerg Med. 2021 Apr;42:15-19.
28. Liteplo AS, Schleifer J, Marill KA, Huang CK, Gouker SK, Ratanski D, Diamond E, Filbin MR, Shokoohi H. Carotid Ultrasound in Assessing Fluid Responsiveness in Patients with Hypotension and Suspected Sepsis. Shock. 2021 Feb 11. doi: 10.1097/SHK.0000000000001755. Epub ahead of print. PMID: 33577247.
29. Eke OF, Henwood PC, Wanjiku GW, Fasina A, Kharasch SJ, Shokoohi H. Global point-of-care ultrasound education and training in the age of COVID-19. Int J Emerg Med. 2021 Feb 18;14(1):12.
30. Kharasch S, Duggan NM, Cohen AR, Shokoohi H. Lung Ultrasound in Children with Respiratory Tract Infections: Viral, Bacterial or COVID-19? A Narrative Review. Open Access Emerg Med. 2020 Oct 14;12:275-285.
31. Liteplo AS, Huang CK, Zheng H, Patel R, Ratanski D, Giordano NJ, Kabrhel C, Shokoohi H. Left Ventricular Dysfunction Correlates With Mortality in Pulmonary Embolism. J Emerg Med. 2021 Feb;60(2):135-143.
32. Goldsmith AJ, Shokoohi H, Loesche M, Patel RC, Kimberly H, Liteplo A. Point-of-care Ultrasound in Morbidity and Mortality Cases in Emergency Medicine: Who Benefits the Most? West J Emerg Med. 2020 Oct 28;21(6):172-178.
33. Hossein-Nejad H, Mehrjerdi MS, Abdollahi A, Loesche MA, Schulwolf S, Ghadipasha M, Mohammadinejad P, Ataeinia B, Shokoohi H. Ultrasound for Intubation Confirmation: A Randomized Controlled Study among Emergency Medicine Residents. Ultrasound Med Biol. 2021 Feb;47(2):230-235.
34. Haney RM, Halperin M, Diamond E, Ratanski D, Shokoohi H, Huang C, Liteplo AS. Clinical Integration of Point-of-care Ultrasound by Emergency Medicine Residents: A Single-center Mixed-methods Study. AEM Educ Train. 2020 Jul 20;4(3):212-222.
35. Duggan NM, Shokoohi H, Liteplo AS, Huang C, Goldsmith AJ. Best Practice Recommendations for Point-of-Care Lung Ultrasound in Patients with Suspected COVID-19, J Emerg Med. 2020;59(4):515-520.
36. Duggan NM, Liteplo AS, Shokoohi H, Goldsmith AJ. Using Lung Point-of-care Ultrasound in Suspected COVID-19: Case Series and Proposed Triage Algorithm. Clin Pract Cases Emerg Med. 2020 Aug;4(3):289-294.
37. Goldsmith AJ, Liteplo A, Hayes BD, Duggan N, Huang C, Shokoohi H. Ultrasound-guided transgluteal sciatic nerve analgesia for refractory back pain in the ED: A case series, Am J Emerg Med. 2020 Sep;38(9):1792-1795..
38. Kharasch SJ, Dumas H, O'Brien J, Shokoohi H, Al Saud AA, Liteplo A, Schleifer J, Kharasch V. Detecting Ventilator-Induced Diaphragmatic Dysfunction Using Point-of-Care Ultrasound in Children With Long-term Mechanical Ventilation. J Ultrasound Med. 2021 Apr;40(4):845-852.
39. Shokoohi H, Pyle M, Kuhl E, Loesche MA, Goyal A, LeSaux MA, Boniface KS, Taheri MR. Optic Nerve Sheath Diameter Measured by Point-of-Care Ultrasound and MRI. J Neuroimaging. 2020 Nov;30(6):793-799.
40. Benton E, Liteplo AS, Shokoohi H, Loesche MA, Yacoub S, Thatphet P, Wongtangman T, Liu SW. A pilot study examining the use of ultrasound to measure sarcopenia, frailty and fall in older patients. Am J Emerg Med. 2020 Aug 7:S0735-6757(20)30676-8.
41. Eke OF, Morone CC, Liteplo AS, Shokoohi H. Non-Covid-19 clinical research in the era of pandemic, Am J Emerg Med. 2021;39:231-232.
42. Patel AK, Mistry K, Breslin K, Shokoohi H, Thomas-Mohtat R. Carotid Artery Flow Time Measured by Point-of-Care Ultrasound Correlates with Volume Changes in Pediatric Hemodialysis Patients. Ultrasound Med Biol. 2020;46(7):1670-1676.
43. Boniface KS, Sikka N, Page N, Peretz A, Shokoohi H. A cruise ship emergency medical evacuation triggered by handheld ultrasound findings and directed by tele-ultrasound. Int Marit Health. 2020;71(1):42-45
44. Goldsmith AJ, Eke OF, Alhassan Al Saud A, Al Mulhim A, Kharasch S, Huang C, Liteplo AS, Shokoohi H. Remodeling Point-of-care Ultrasound Education in the Era of COVID-19. AEM Educ Train. 2020 Jun 7;4(3):321-324.
45. Jaffe TA, Shokoohi H, Liteplo A, Goldsmith A. A Novel Application of Ultrasound-Guided Interscalene Anesthesia for Proximal Humeral Fractures. J Emerg Med. 2020;59(2):265-269.
46. Goldsmith AJ, Liteplo AS, Shokoohi H. Ultrasound-Guided Serratus Anterior Plane Block for Intractable Herpes Zoster Pain in the Emergency Department, J Emerg Med. 2020;59(3):409-412.
47. Kharasch SJ, Jansson P, Liteplo AS, Gouker S, Longacre M, Shokoohi H, Schleifer J. The Use of Point-of-Care Ultrasound to Evaluate Pulsus Paradoxus in Children With Asthma. J Ultrasound Med. 2020 Mar;39(3):625-632.
48. Shokoohi H, Nasser S, Pyle M, Earls JP, Liteplo A, Boniface K. Utility of point-of-care ultrasound in patients with suspected diverticulitis in the emergency department. J Clin Ultrasound. 2020;48(6):337-342
49. Hensley B, Huang C, Cruz Martinez CV, Shokoohi H, Liteplo A. Ultrasound Measurement of Carotid Intima-Media Thickness and Plaques in Predicting Coronary Artery Disease. Ultrasound Med Biol. 2020;46(7):1608-1613.
50. Boniface K, Pyle M, Jaleesah N, Shokoohi H. Point-of-Care Ultrasound for the Detection of Hip Effusion and Septic Arthritis in Adult Patients With Hip Pain and Negative Initial Imaging. J Emerg Med. 2020;58(4):627-631
51. Ogle K, Mandoorah S, Fellin M, Shokoohi H, Probasco W, Boniface K. Point-of-care Ultrasound Diagnosis of Bilateral Patellar Tendon Rupture. Clin Pract Cases Emerg Med. 2020;4(1):29-31
52. Shokoohi H, Duggan NM, García-de-Casasola Sánchez G, Torres-Arrese M, Tung-Chen Y. Lung ultrasound monitoring in patients with COVID-19 on home isolation, Am J Emerg Med. 2020;38(12):2759.e5-2759.e8.
53. Haney RM, Graglia S, Schleifer J, Mendoza A, Frasure SE, Shokoohi H, Huang C, Liteplo AS.. Interdisciplinary approach to enhance trauma residents education of Extended-Focused Assessment for Sonography in Trauma in the emergency department. ANZ J Surg. 2020;90(9):1700-1704.
54. Molina MF, Al Saud AA, Al Mulhim AA, Liteplo AS, Shokoohi H. Nitrous oxide inhalant abuse and massive pulmonary embolism in COVID-19, Am J Emerg Med. 2020;38(7):1549.e1-1549.e2.
55. Shokoohi H, Boniface KS, Loesche MA, Duggan NM, King JB. Development of a nomogram to predict small bowel obstruction using point-of-care ultrasound in the emergency department [published online ahead of print, 2019 Dec 16]. Am J Emerg Med. 2019;S0735-6757(19)30806-X
56. Boniface KS, King JB, LeSaux MA, Haciski SC, Shokoohi H. Diagnostic Accuracy and Time-Saving Effects of Point-of-Care Ultrasonography in Patients with Small Bowel Obstruction: A Prospective Study. Ann Emerg Med. 2020 Feb;75(2):246-256
57. Boniface K, Drake A, Pyle M, Moideen F, Mehta S, Gopal V, Shokoohi H, Douglass K. Learner-centered survey of point-of-care ultrasound training, competence, and implementation barriers in emergency medicine training programs in India- AEM Education and Training- 2020 Feb 7;4(3):331-335
58. Shokoohi H, Goldsmith A, Negishi K, Herrala J, Diamond E, Kharasch S, Blaivas M, Liteplo A. A novel measure for characterizing ultrasound device use and wear. JACEP Open. April 2020;1-6. https://doi.org/10.1002/emp2.12051
59. Boniface KS, Ogle K, Aalam A, LeSaux M, Pyle M, Mandoorah S, Shokoohi H. Direct Observation Assessment of Ultrasound Competency Using a Mobile SDOT Application with Comparison to Asynchronous Quality Assurance Evaluation. AEM Educ Train. 2019 Feb 19;3(2):172-178
60. Shokoohi H, Raymond A, Fleming K, Scott J, Kerry V, Haile-Mariam T, Sayeed S, Boniface KS. Assessment of the Point-of-Care Ultrasound Training for Clinical Educators in Malawi, Tanzania and Uganda. Ultrasound Med Biol. 2019 Jun;45(6):1351-1357.
61. Graglia S, Huang C, Shokoohi H, Liteplo AS. Faculty opinions concerning ultrasound utilization in the emergency department. Am J Emerg Med. 2019 Jul;37(7):1372-1374.
62. Molina M, Liteplo AS, Huang C, Shokoohi H. Diagnostic considerations in detecting apical hypertrophic cardiomyopathy while utilizing point-of-care ultrasound. Am J Emerg Med. 2019 Aug;37(8):1596-1598.
63. Shokoohi H, Boniface KS, Kulie P, Long A, McCarthy M. The Utility and Survivorship of Peripheral Intravenous Catheters Inserted in the Emergency Department. Ann Emerg Med. 2019 Sep;74(3):381-390.
64. Shokoohi H, Pyle M, Frasure SE, Dimbil U, Pourmand A. Point-of-care Transperineal Ultrasound to Diagnose Abscess in the Emergency Department. Clin Pract Cases Emerg Med. 2019 Sep 18;3(4):349-353
65. Shokoohi H, Pourmand A, Boniface, K, Philips J. The Utility of Point-of-Care Ultrasound in Targeted Automobile Ramming Mass Casualty (TARMAC) Attacks – Am J Emerg Med. 2018 Aug;36(8):1467-1471.
66. Boniface KS, Raymond A, Fleming K, Scott J, Kerry VB, Haile-Mariam T, Sayeed S, Shokoohi H. The Global Health Service Partnership's point-of-care ultrasound initiatives in Malawi, Tanzania and Uganda. Am J Emerg Med. 2019 Apr;37(4):777-779.
67. Shokoohi H, LeSaux M, Rohani Y, Haung C, Liteplo A, Blaivas M. Enhanced Point-of-Care Ultrasound Applications by Integrating Automated Feature-Learning Systems Using Deep Learning. J Ultrasound Med. 2019 Jul;38(7):1887-1897.
68. Buhumaid RE, St-Cyr Bourque J, Shokoohi H, Ma IWY, Longacre M, Liteplo AS. Integrating point-of-care ultrasound in the ED evaluation of patients presenting with chest pain and shortness of breath. Am J Emerg Med. 2019 Feb;37(2):298-303.
69. Shokoohi H, Pourmand A, Boniface, K, Philips J. The Utility of Point-of-Care Ultrasound in Targeted Automobile Ramming Mass Casualty (TARMAC) Attacks – Am J Emerg Med. 2018 Aug;36(8):1467-1471.
70. Azad AM, Al Madi HA, Abdull Wahab SF, Shokoohi H, Kang YJ, Liteplo AS. Gastric ultrasonography in evaluating NPO status of pediatric patients in the emergency department. Am J Emerg Med 2018; [pubmed]
71. Boniface KS, Raymond A, Fleming K, Shokoohi H. The Global Health Service Partnership's point-of-care ultrasound initiatives in Malawi, Tanzania and Uganda. Am J Emerg Med 2018; [pubmed]
72. Huang C, Shokoohi H, Przybylo JA, et al. INSPIRED: Instruction of sonographic placement of IVs by registered nurses in the emergency department. Am J Emerg Med 2018; [pubmed]
73. Shokoohi H, Pourmand A, Boniface K, et al. The utility of point-of-care ultrasound in targeted automobile ramming mass casualty (TARMAC) attacks. Am J Emerg Med 2018; 36(8):1467-1471. [pubmed]
74. Liteplo AS, Carmody K, Fields MJ, Liu RB, Lewiss RE. SonoGames: Effect of an Innovative Competitive Game on the Education, Perception, and Use of Point-of-Care Ultrasound. J Ultrasound Med 2018; [pubmed]
75. Longacre M, Kharasch S, Liteplo A. Letter to the Editor regarding recent American Journal of Emergency Medicine article in press: "Point of care lung ultrasound of children with acute asthma exacerbations in the pediatric emergency department" by Dankoff et al. Am J Emerg Med 2017; 35(10):1575-1576. [pubmed]
76. Ma IWY, Caplin JD, Azad A, et al. Correlation of carotid blood flow and corrected carotid flow time with invasive cardiac output measurements. Crit Ultrasound J 2017; 9(1):10. [pubmed]
77. Henwood PC, Mackenzie DC, Liteplo AS, et al. Point-of-Care Ultrasound Use, Accuracy, and Impact on Clinical Decision Making in Rwanda Hospitals. J Ultrasound Med 2017; 36(6):1189-1194. [pubmed]
78. Rempell JS, Saldana F, DiSalvo D, et al. Pilot Point-of-Care Ultrasound Curriculum at Harvard Medical School: Early Experience. West J Emerg Med 2016; 17(6):734-740. [pubmed]
79. Nelson M, Abdi A, Adhikari S, et al. Goal-directed Focused Ultrasound Milestones Revised: A Multiorganizational Consensus. Acad Emerg Med 2016; 23(11):1274-1279. [pubmed]
80. Henwood PC, Mackenzie DC, Rempell JS, et al. Intensive point-of-care ultrasound training with long-term follow-up in a cohort of Rwandan physicians. Trop. Med. Int. Health 2016; 21(12):1531-1538. [pubmed]
81. Lewiss RE, Adhikari S, Carmody K, et al. The Society of Clinical Ultrasound Fellowships: An innovation in the point of care ultrasound fellowship application process. Am J Emerg Med 2016; 34(7):1303-5. [pubmed]
82. Mackenzie DC, Khan NA, Blehar D, et al. Carotid Flow Time Changes With Volume Status in Acute Blood Loss. Ann Emerg Med 2015; 66(3):277-282.e1. [pubmed]
83. Lam SH, Bailitz J, Blehar D, et al. Multi-Institution Validation of an Emergency Ultrasound Image Rating Scale-A Pilot Study. J Emerg Med 2015; 49(1):32-39.e1. [pubmed]
84. Lewiss RE, Hayden GE, Murray A, Liu YT, Panebianco N, Liteplo AS. SonoGames: an innovative approach to emergency medicine resident ultrasound education. J Ultrasound Med 2014; 33(10):1843-9. [pubmed]
85. Liu YT, Zehtabchi S, Liteplo AS. Ultrasound and the six thinking hats. Acad Emerg Med 2014; 21(8):920-1. [pubmed]
86. Via G, Hussain A, Wells M, et al. International evidence-based recommendations for focused cardiac ultrasound. J Am Soc Echocardiogr 2014; 27(7):683.e1-683.e33. [pubmed]
87. Henwood PC, Mackenzie DC, Rempell JS, et al. A practical guide to self-sustaining point-of-care ultrasound education programs in resource-limited settings. Ann Emerg Med 2014; 64(3):277-285.e2. [pubmed]
88. Gaspari RJ, Blehar D, Polan D, Montoya A, Alsulaibikh A, Liteplo A. The Massachusetts abscess rule: a clinical decision rule using ultrasound to identify methicillin-resistant Staphylococcus aureus in skin abscesses. Acad Emerg Med 2014; 21(5):558-67. [pubmed]
89. Lewiss RE, Tayal VS, Hoffmann B, et al. The core content of clinical ultrasonography fellowship training. Acad Emerg Med 2014; 21(4):456-61. [pubmed]
90. Brattain LJ, Telfer BA, Liteplo AS, Noble VE. Automated B-line scoring on thoracic sonography. J Ultrasound Med 2013; 32(12):2185-90. [pubmed]
91. Sheng AY, Dalziel P, Liteplo AS, Fagenholz P, Noble VE. Focused Assessment with Sonography in Trauma and Abdominal Computed Tomography Utilization in Adult Trauma Patients: Trends over the Last Decade. Emerg Med Int 2013; 2013():678380. [pubmed]
92. Howard ZD, Noble VE, Marill KA, et al. Bedside ultrasound maximizes patient satisfaction. J Emerg Med 2014; 46(1):46-53. [pubmed]
93. Mackenzie DC, Liteplo AS, Noble VE. Sensitivity of point-of-care ultrasonography for common thoracic injuries. Chest 2013; 143(1):269. [pubmed]
